Uromodulin is a kidney-specific glycoprotein, which is mainly secreted in the urine but also, in small amounts, into the bloodstream. Since it was discovered several years ago that mutations and certain polymorphisms in the uromodulin-coding gene (UMOD) are associated with various kidney disorders and kidney vitality, the protein has been increasingly researched. Today, uromodulin is […]
Uromodulin is a kidney-specific glycoprotein, which is exclusively expressed by the epithelial cells of the ascending limb of loop of Henle (TAL cells) and secreted into the urine. There, it is the quantitatively most significant protein. Additionally, secretion of small quantities of uromodulin into the interstitium was described. In this way the proteins gets into
Clinicians and biologists expect increasing numbers of infections with hantaviruses in Germany this year due to the ongoing strong reproduction of the bank vole and the striped field mouse. The rodents function as reservoirs and spread the virus through their excrements. Dust, contaminated with the pathogen, may be inhaled by humans when sweeping a shed
A large cross-sectional serostudy of blood donors in Saudi Arabia has revealed a significant number of subclinical infections with Middle East respiratory syndrome coronavirus (MERS), which pose a likely source of infection in previously unexplained outbreaks of MERS. Notably, the prevalence of antibodies against MERS coronavirus (MERS-CoV) was significantly higher in persons with regular exposure
Spring is coming and you can tell: the sun is up earlier in the morning, the birds are singing, early bloomers can be seen in the gardens and by the wayside, and, another sure sign, people who are allergic to pollen start sneezing and sniffling. Even experts are unable to explain why some people develop
