Publication @en Archive - Page 2 of 4

Excellent performance of the automated CLIFT evaluation by the “EUROPattern Suite”

Dr. Konstantin Ens / 1. December 2015

Antibodies against double stranded DNA (anti-dsDNA) are immunological indicators for systemic lupus erythematosus (SLE), a severe rheumatic autoimmune disease. According to the recommendations of the American College of Rheumatology, their detection constitutes an important criterion for the diagnosis of the disease [1]. Among the commonly applied test systems, indirect immunofluorescence on the flagellate Crithidia luciliae […]

Science

Treatment of bullous pemphigoid: immune adsorber binds specific antibodies

Dr. Oliver Sendscheid / 19. November 2015

Bullous pemphigoid (BP) is considered the most frequent autoimmune blistering disease with an incidence of about 1.5 to 2 per 100,000 inhabitants and year in the general population. The disease becomes even more frequent in the elderly. The clinical picture of BP includes tense blisters, formation of erythema, erosions, crusts and pruritus. The presence of

Science

Dromedaries on the Canary Islands, seropositive for anti-MERS-CoV antibodies, originate from Africa

Dr. Konstanze Stiba / 23. October 2015

In 2012, a new coronavirus was identified in the Middle East causing a respiratory syndrome in humans (Middle East Respiratory Syndrome coronavirus, MERS-CoV). Camels were shown to be a major reservoir for the virus and a potential source for human infections. Although transmission of the virus from animals to humans as well as humans to

Science

Inflammatory bowel diseases: immune reaction against intestinal microbiota

Dr. Dominik Jäger / 9. October 2015

Our body, especially the intestine, is colonized by a huge number of microbes – ten times more than the body’s own eukaryotic cells. This overcrowding, which seems rather alarming at first glance, fulfills important functions. Although bacteria are commonly associated with diseases, many of these microbes are harmless or even beneficial for humans. Indeed, the

Science

Autoantibody diagnostics in autoimmune nephropathies

Dr. Oliver Sendscheid / 22. September 2015

Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against renal proteins, as in the case of primary membranous nephropathy (MN) or Goodpasture syndrome, or may occur secondary as part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE). The detection of specific autoantibodies in patient